Thomas Haaf Selected Research

hydrogen sulfite (bisulfite)

1/2022	Hypermethylation of RAD9A intron 2 in childhood cancer patients, leukemia and tumor cell lines suggest a role for oncogenic transformation.
1/2022	Ribosomal DNA methylation in human and mouse oocytes increases with age.
1/2018	Single CpG hypermethylation, allele methylation errors, and decreased expression of multiple tumor suppressor genes in normal body cells of mutation-negative early-onset and high-risk breast cancer patients.
3/2015	In vitro maturation of oocytes is not associated with altered deoxyribonucleic acid methylation patterns in children from in vitro fertilization or intracytoplasmic sperm injection.
12/2014	Epigenetic heterogeneity of developmentally important genes in human sperm: implications for assisted reproduction outcome.
4/2014	Widespread differences in cortex DNA methylation of the "language gene" CNTNAP2 between humans and chimpanzees.
11/2012	Constitutive promoter methylation of BRCA1 and RAD51C in patients with familial ovarian cancer and early-onset sporadic breast cancer.
3/2010	Extreme methylation values of imprinted genes in human abortions and stillbirths.

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Thomas Haaf Research Topics

Disease

10	Neoplasms (Cancer) 01/2022 - 01/2002
5	Hearing Loss (Hearing Impairment) 11/2020 - 02/2009
3	Second Primary Neoplasms (Neoplasms, Second) 01/2022 - 01/2011
3	Sensorineural Hearing Loss 06/2021 - 11/2018
3	Nonsyndromic Deafness 01/2020 - 02/2014
2	Carcinogenesis 01/2022 - 01/2002
2	Premature Aging 10/2019 - 01/2016
2	Auditory neuropathy 02/2018 - 01/2018
2	CAPOS syndrome 02/2018 - 01/2018
2	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 01/2018 - 07/2017
2	Obesity 01/2017 - 01/2016
2	Stillbirth 09/2010 - 03/2010
1	Charcot-Marie-Tooth Disease (Peroneal Muscular Atrophy) 10/2022
1	Male Infertility (Male Sterility) 01/2022
1	Leukemia 01/2022
1	Laminopathies 01/2022
1	Werner Syndrome (Werner's Syndrome) 01/2022
1	Progeria (Hutchinson Gilford Syndrome) 01/2022
1	Down Syndrome (Down's Syndrome) 01/2022
1	Multiple Myeloma 11/2021
1	Hematologic Neoplasms (Hematological Malignancy) 11/2021
1	Deafness (Deaf Mutism) 06/2021
1	Glucose Intolerance 04/2021
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2021
1	Loeys-Dietz Syndrome 01/2021
1	Autosomal Recessive 32 Deafness 01/2020
1	Dyslipidemias (Dyslipidemia) 01/2020
1	Non-alcoholic Fatty Liver Disease 01/2020
1	Hyperglycemia 01/2020
1	Insulin Resistance 01/2020
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2020
1	Amyloid Plaque 12/2019
1	Alzheimer Disease (Alzheimer's Disease) 12/2019
1	Cognitive Dysfunction 12/2019
1	Adenoma (Adenomas) 11/2019
1	Colorectal Neoplasms (Colorectal Cancer) 11/2019
1	Diffuse Scleroderma (Progressive Systemic Sclerosis) 10/2019
1	Infantile Spasms (West Syndrome) 11/2018
1	Cataract (Cataracts) 11/2018
1	Talipes Cavus (Pes Cavus) 02/2018
1	Cerebellar Ataxia (Dysmetria) 02/2018
1	Optic Atrophy 02/2018
1	Triple Negative Breast Neoplasms 01/2018
1	Brain Diseases (Brain Disorder) 01/2017
1	Tinnitus 01/2017
1	Mental Disorders (Mental Disorder) 01/2017
1	Polyploidy 11/2016
1	Anxiety Disorders (Anxiety Disorder) 01/2016
1	Panic Disorder (Panic Attack) 01/2016
1	Chromosomal Instability (Chromosome Stability) 09/2015
1	Oligospermia (Oligozoospermia) 12/2014
1	Autistic Disorder (Autism) 04/2014
1	Gestational Diabetes (Gestational Diabetes Mellitus) 04/2013
1	Ovarian Neoplasms (Ovarian Cancer) 11/2012

Drug/Important Bio-Agent (IBA)

11	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2002
8	hydrogen sulfite (bisulfite)IBA 01/2022 - 03/2010
7	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 01/2002
5	Messenger RNA (mRNA)IBA 07/2017 - 01/2002
4	Glucose (Dextrose)FDA LinkGeneric 04/2021 - 01/2017
3	snRNP Core ProteinsIBA 03/2015 - 03/2010
2	Adenosine Triphosphatases (ATPase)IBA 02/2018 - 01/2018
2	Insulin (Novolin)FDA Link 04/2013 - 09/2009
1	Tryptophan-tRNA LigaseIBA 10/2022
1	Long Noncoding RNAIBA 01/2022
1	Biomarkers (Surrogate Marker)IBA 01/2022
1	beta CateninIBA 01/2022
1	Ribosomal DNA (rDNA)IBA 01/2022
1	ElementsIBA 01/2022
1	Immunomodulating AgentsIBA 11/2021
1	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2021
1	RNA Splice SitesIBA 01/2020
1	Insulin ReceptorIBA 01/2020
1	Growth Differentiation Factor 15IBA 01/2020
1	Myosins (Myosin)IBA 01/2020
1	Amyloidogenic ProteinsIBA 12/2019
1	CytosineIBA 11/2019
1	Unithiol (DMPS)IBA 11/2019
1	Formaldehyde (Formol)FDA Link 11/2019
1	ParaffinIBA 11/2019
1	Phosphates (Orthophosphate)IBA 11/2019
1	GuanineIBA 11/2019
1	CytokinesIBA 10/2019
1	Transcription Factors (Transcription Factor)IBA 10/2019
1	RNA Polymerase II (RNA Polymerase B)IBA 10/2019
1	Growth Hormone (Somatotropin)IBA 11/2018
1	Estrogen ReceptorsIBA 01/2018
1	human ERBB2 proteinIBA 01/2018
1	Amino Acids FDA Link 01/2018
1	ProtocadherinsIBA 01/2017
1	Toll-Like Receptors (Toll-Like Receptor)IBA 11/2016
1	Conditioned Culture MediaIBA 01/2016
1	Forkhead Transcription Factors (Forkhead Box Proteins)IBA 01/2016
1	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2016
1	Aligeron (AS 2)IBA 03/2015
1	A-Form DNA (A-DNA)IBA 12/2014
1	Collagen Type IV (Type IV Collagen)IBA 02/2014
1	Complementary DNA (cDNA)IBA 02/2013

Therapy/Procedure

2	Therapeutics 01/2017 - 01/2017
1	Cochlear Implantation 02/2018
1	Hearing Aids (Hearing Aid) 02/2018